Choless Control cholesterol control formula
for cholesterol reduction.
Choless Control Product Ingredients:
Two
2-Piece Capsules Provide
Policosanol
10 MG
Policosanol has been shown to normalize
cholesterol as well or better than
cholesterol-lowering drugs, without side effects
such as liver dysfunction and muscle atrophy.1
Efficacy and safety have been proven in numerous
clinical trials, and it has been used by millions
of people in other countries. Policosanol lowers
harmful LDL-cholesterol and raises protective HDL-cholesterol.
HDL-cholesterol removes plaque from arterial
walls.
Policosanol
is a natural supplement derived from sugar cane.
The main ingredient is octacosanol. Octacosanol is
an alcohol found in the waxy film that plants have
over their leaves and fruit. The leaves and rinds
of citrus fruits contain octacosanol, and so does
wheat germ oil.
Policosanol
helps stop the formation of artery lesions,2 an
effect similar to that of statin drugs. This was
proven in studies on rabbits fed a diet designed
to create high cholesterol. According to
researchers "in most policosanol-treated
animals, atherosclerotic lesions were not present,
and in others, thickness of fatty streaks had less
foam cell layers than in controls.,3
Policosanol
also inhibits the oxidation of dangerous
LDL-cholesterol4 which promotes the destruction of
blood vessels by creating a chronic inflammatory
response. Oxidized LDL can also provoke
metalloproteinase enzymes.5 These enzymes promote
blood vessel destruction, partly by interfering
with HDL's protective effect. Studies show that
rats treated with policosanol have fewer foam
cells, reflecting less inflammatory response
causing less blood vessel destruction.6,7
Healthy
arteries are lined with a smooth layer of cells so
that blood can race through with no resistance.
One of the features of diseased arteries is that
this layer becomes thick and overgrown with cells.
As the artery narrows, blood flow slows down or is
blocked completely. Policosanol can stop the
proliferation of these cells in much the same was
as lipid-lowering drugs.8,9
Policosanol
also inhibits the formation of clots, and may work
synergistically with aspirin in this respect. In a
comparison of aspirin and policosanol, aspirin was
better at reducing one type of platelet
aggregation (clumping together of blood cells).
But policosanol was better at inhibiting another
type. Together, policosanol and aspirin worked
better than either alone.10,11
Thromboxane
is a blood vessel-constricting agent that
contributes to abnormal platelet aggregation that
can cause a heart attack or stroke. Significant
reductions in the level of thromboxane occur in
humans after two weeks of policosanol.12
People
with elevated LDL-cholesterol (over 100) or low
HDL-cholesterol (under 50) should seek to protect
themselves from the potentially fatal effects of
cardiovascular disease. Some people can achieve
optimal cholesterol levels via dietary
modification, while others require intervention
with dietary supplements like policosanol or
prescription drugs.
Some
people will not achieve adequate results with
policosanol or FDA-approved cholesterol-lowering
drugs. That is why it is so important to have your
blood tested when using policosanol (or
FDA-approved drugs). Some people will only require
5 mg to 10 mg a day of policosanol, while others
may need 20 mg/day. The same dosage variation may
be true of cholesterol-lowering drugs.
A
standard blood chemistry profile measures total
cholesterol, LDL-cholesterol, HDL-cholesterol and
numerous other parameters such as liver and kidney
function. By taking this blood test two months
after beginning policosanol, you can adjust the
dose to meet your individual need.
Benefits
of Policosanol
Lowers cholesterol without life-threatening side
effects
Elevates HDL better than most statin drugs
Inhibits the formation of lesions in arteries
Keeps LDL from oxidizing
Enhances the benefits of exercise
Reduces complications in people with artery
diseases
Reduces thromboxane which promotes
inflammation
Doesnt interfere with sex life
Niacin
50 MG
Niacin (vitamin B3) improves cholesterol profiles
when given in doses well above the vitamin
requirement. Nicotinic acid lowers total
cholesterol, LDL-cholesterol, and triglyceride
levels, while raising HDL-cholesterol levels. Most
people cannot use the doses (1000 to 3000 mg a
day) of niacin required to suppress cholesterol
levels. Niacin causes a flushing effect,
resembling an acute allergic reaction that many
people find intolerable. While niacin is
considered relatively safe, like other
cholesterol-lowering drugs, it can cause liver
toxicity when taken in high doses. Monitoring
liver enzymes every 6 months is important when
taking more than 1000 mg of niacin a day. Those
with hepatitis should avoid niacin.
Flush-free niacin may lower cholesterol while
boosting the beneficial HDL fraction. In a report
on the antiatherogenic role of HDL (high density
lipoprotein) cholesterol, flush-free niacin (inositol
hexanicotinate) "appears to have the greatest
potential to increase HDL cholesterol [by]
30%." This study was made over a 5-year
period and focused on the effect of high LDL
numbers exhibited before a patient's first
coronary event(s).
As reported in a November 1998 American Journal of
Cardiology research study, "Nicotinic acid
(niacin) has been shown to decrease triglyceride,
increase HDL cholesterol, lower LDL cholesterol,
and decrease lipoprotein (a); it also decreases
fibrinogen," an additional benefit that
reduces the risk of related cardiovascular
disease.
To determine whether lower doses of nicotinic acid
are as effective and better-tolerated than the
typical regimen currently used, researchers at the
University of Texas Southwestern Medical Center in
Dallas, as reported and described in the Archives
of Internal Medicine, 1996, conducted a trial
using two different doses (1.5 g and 3.0 g) of
nicotinic acid.
The results showed that the lower dose (1.5 g )
nicotinic acid treatment significantly lowered
triglyceride levels, raised HDL concentrations by
approximately 22%, and favorably altered the ratio
of total cholesterol: HDL cholesterol in both
normal patients and those with abnormal lipid
levels at baseline. Further improvement in lipid
levels was also observed in those patients who
tolerated the higher dose of nicotinic acid.
In this study, significant improvement in blood
lipids levels was observed among the 75% of
patients who tolerated low-dose nicotinic acid
therapy. The authors conclude that use of
nicotinic acid in lower doses than traditionally
prescribed is both well-tolerated and effective in
altering blood lipid levels. In addition, they
suggest that this vitamin may be particularly
worthwhile when combined with other lipid-lowering
medications.
Gugulipid
(2.5% gugglesterones) 100 MG
This powerful ancient remedy has been
re-discovered by Western culture. Gugulipid is
made from the resin of the commiphora mukul tree
of north central India. Gugulipid (gugulesterones)
has been used for thousands of years to alleviate
problems associated with obesity, acne, viral
infections, and other ailments.
In a study published in 1989 by the Journal of
Associated Physicians-India, 125 patients
receiving gugulipid showed an 11% decrease in
total serum cholesterol, a drop of 16.8% in
triglycerides, and a 60% increase in HDL
cholesterol within 3 to 4 weeks. Patients with
elevated cholesterol levels showed much greater
improvement than normal patients.
The study quoted a second trial (included in the
article noted above) where 205 patients receiving
gugulipid at a dose rate of 25 mg administered 3
times daily showed a 70 to 80% reduction of serum
cholesterol, whereas no response was found in the
placebo group (Journal of Associated
Physicians-India, 1989, 37[5]:328).
A placebo-controlled trial of 40 patients with
high blood-fat levels showed a serum cholesterol
reduction of 21.75%, with triglycerides being
reduced by 27.1% in only 3 weeks, and after
continuing the study for 16 weeks it was learned
that HDL cholesterol was increased by 35.8%
(Journal of Associated Physicians-India, 1989,
37[5]:328).
Plant
Sterol Complex 200 MG
Phytosterols (PS) or plant sterols are
structurally similar to cholesterol which causes
the absorption of cholesterol to be blocked
through competitive inhibition.. Studies suggest
that dietary plant sterols may offer protection
from the most common cancers in Western societies,
such as colon, breast and prostate cancer
Garlic
(herb powder) 50 MG
A study published in the Journal Nutrition
Research (1987, 7:139-49) showed that a liquid
garlic extract made by Kyolic caused a 12 to 31%
reduction in cholesterol levels in the majority of
test subjects after 6 months. The study showed
that 73% of the subjects given the Kyolic garlic
experienced a greater than 10% reduction in
cholesterol, compared with only 17% of the
subjects in the placebo group showing the same
improvement.
If you have high LDL cholesterol levels, garlic
supplementation is especially important because
LDL cholesterol oxidation causes atherosclerosis,
and garlic specifically inhibits LDL oxidation.
And garlic helps protect the arterial lining
against oxidation. Most importantly, garlic
prevents abnormal platelet aggregation
(thrombosis) via several different mechanisms. The
formation of arterial blood clots is the primary
cause of most heart attacks and strokes.
Investigators reported in a study published in the
American Journal of Clinical Nutrition (1996,
64:866-70) that the daily administration of 7.2
grams of Kyolic garlic powder for 6 months
produced a modest reduction (of between 6.1 and
7%) in total cholesterol, compared with the
placebo group. The more dangerous LDL cholesterol
was reduced 4 to 4.6% in the Kyolic group.
The heart-healthy benefits of garlic include
protecting the endothelial lining of the arterial
system against oxidative damage. A study published
in Atherosclerosis (1999, 144:237-49) shows an
actual reduction in buildup of fatty plaque in
arteries in garlic-supplement users. Fatty plaque
is comprised of many substances, including
cholesterol. When plaque accumulates in the
coronary arteries, the condition can lead to heart
attack. In a study of 280 adults, German
researchers reported that participants who took
900 mg of garlic powder a day had up to 18% less
plaque in their arteries than those who took a
placebo, or "dummy," powder. Male study
participants who took a placebo had a 5.5%
increase in plaque volume, while those who took
the garlic powder experienced just a 1.1% increase
in plaque buildup during the 4-year study period.
By comparison, women who took the garlic showed a
4.6% decrease in plaque volume, while those who
took the placebo powder had a 5.3% increase.
Garlic may affect plaque buildup by reducing blood
platelet stickiness (aggregation) and specifically
preventing the oxidation of LDL cholesterol onto
the lining of the arteries. Platelet aggregation
helps plaque cling to the arteries.
An April 1998 study reported on the effect of
garlic on blood lipids, blood sugar fibrogen, and
fibrinogenic activity of 30 patients who received
4 grams of garlic daily for 3 months. The patients
were monitored at 1.5 and 3 months when it was
determined that garlic had "significantly
reduced total serum cholesterol and triglycerides,
and significantly increased HDL cholesterol."
With regard to fibrinogenic activity, it was
determined that the garlic inhibited platelet
aggregation (Prostagland. Leuk. Essent. Fatty
Acids, April 1998, 58[4]:257-63).
An earlier study in June 1994, the University of
Massachusetts Medical School published a report
that found that those U.S. adults who consumed
one-half to one clove of garlic each day showed
cholesterol levels that were reduced by 9% (JAMA,
June 1, 1994, 271[21]:1660-61). A survey of 7 out
of 8 studies on garlic showed that dosages of
between 600 to 900 mg of garlic powder (Allium
sativum L.) produced a 5 to 20% reduction in
cholesterol and triglycerides. (Fortschr. Med.
(Germany) 1990, 108[36]:49-54). Other studies have
shown that much higher doses of garlic were
required for cholesterol reduction.
Human patients fed a daily dose of Kyolic
("Aged Garlic Extract") over a 10-month
study showed that "adhesion to fibrinogen was
reduced by 30%-compared to placebo . . . and that
. . . the beneficial effect of garlic preparations
on lipids and blood pressure extends also to
platelet function" (Journal of Cardiovascular
Pharmacology [United States], 1998, 31[6]:904-8).
Note: Overall studies seem to indicate that
dosages of garlic may be a factor in its efficacy.
The suggested dose of high allicin garlic extract
should be between 6000 mg and 8000 mg daily taken
with meals. Since large amounts of garlic may
cause stomach upset, we recommend that garlic be
taken with the largest meal of the day.
In summary, the mechanisms by which garlic have
shown to protect against cardiovascular disease
include the following: cholesterol reduction,
preventing abnormal blood clot formation inside of
blood vessels; protecting against LDL cholesterol
oxidation; and protecting the endothelial lining
of the arterial system against oxidation. A review
of all the studies on garlic indicates that high
doses are required for effective cholesterol
reduction. If you were to use garlic alone to
lower serum cholesterol, you should take 6000 to
8000 mg a day. When used in combination with other
cholesterol-lowering nutrients, lower doses of
garlic may be effective.
Cayenne
Pepper ...................50 MG
Inhibits LDL oxidation
Caution:
Policosanol should only be taken by people who
have high serum cholesterol levels. The optimal
range of total serum cholesterol is between 180
and 200 mg/dL. Cholesterol levels below 180 cause
an increased risk of mortality and levels below
150 may be very dangerous. It may be particularly
risky for people over age 70 to have cholesterol
levels below 150-180. DO NOT TAKE policosanol if
it causes serum cholesterol to drop below 150-180
mg/dL. Anyone supplementing with policosanol
should check their total, LDL- and HDL-cholesterol
levels within 8 weeks of beginning treatment to
make sure they are taking the proper amount to
modify cholesterol to the optimal safe ranges. If
you are currently taking cholesterol-lowering
drugs, you should notify your doctor if you plan
to use policosanol instead of, or in addition to
these drugs. Some people who do not adequately
suppress cholesterol with drug therapy may choose
to add policosanol to achieve better cholesterol
control. Pregnant or nursing Women should not take
this product without consulting with a healthcare
professional. When using nutritional supplements,
please inform your healthcare professional if you
are undergoing treatment for a medical condition.
Note: These statements have not been evaluated by
the Food and Drug Administration. Policosanol is a
dietary supplement and not a drug approved by the
FDA.
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Cholesterol Control Formula
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